This act is regarded by most Westerners as merely odd, but it was, in fact, profoundly consistent with the enduring character of Japanese civilization.
Interestingly however, mixing tra mutants with WT cells perturbs motility and development profoundly, consistent with a role in the control population dynamics (Pathak et al., 2012).
Auditory brainstem response (ABR) analysis demonstrated that mice homozygous for the missense mutation are profoundly deaf, consistent with an essential role for otoferlin in inner hair cell neurotransmission.
Importantly, You and colleagues demonstrated that proliferated alloreactive T cells precipitate apoptosis more profoundly, a finding consistent with our data in vitro where anti-CD3 therapy was found to promote apoptosis of TCR+ lymphocytes after alloantigen stimulation (data not shown).
This is consistent with a profoundly abnormal StO2 recovery slope after VOT in our patients with a low lactate clearance, suggesting a persistent microvascular dysfunction.
Consistent with the profoundly increased cardiac remodelling in the PLM3SA mice, the hypertrophy-induced increase in cell size was significantly greater in myocytes from banded PLM3SA vs. banded WT mice.
However, on nutrient-rich diet, RICTOR mutants showed a profoundly extended life span, which is consistent with decreased consumption of nutrient-rich food by mutants (Soukas et al., 2009).
The results presented below extend this concept to postsynaptic terminals, the largest consumers of energy in the brain, and are consistent with energy use profoundly constraining the operation of the CNS.
Amy's profoundly raw pain and her rageful, obsessive plotting is consistent with the withdrawal phase of Love Addiction.
However, the profoundly decreased physical activity of the TG mice is consistent with "sickness behavior" [ 49, 50].
In addition, GCs rapidly and profoundly increase expression of multiple genes, many with properties consistent with the repression of inflammatory gene expression [ 9].
