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The parents of patients affected by this condition are subject to particularly stressful situations, such as worrying about their child's health, long hospital stays, concerns about the health and constant need for personal care for their children, that can profoundly compromise the quality of family life.
Indeed, BD exposure induced profound DNA damage, especially the formation of N-7 guanine adducts, whose presence may profoundly compromise the methylation capacity of Dnmt1, as has been observed with other guanine adducts (Valinluck and Sowers 2007).
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It may seem extreme to make comparison with this other great, but profoundly compromised film-maker, but there are real echoes.
Welfare researchers agree that the welfare of zoo animals can be profoundly compromised when they don't have opportunities to procure their own food, solve problems in their environment, or engage with others of their kind.
And yet, in imprinting its own version of one of Thackeray's terrible photographs, the movie gives us an unindulgent, clear-eyed and magnificent version of a profoundly compromised human life.
Due to these ambiguities, the campaign credibility could be profoundly compromised.
Conversely, knockdown of Tfcp2l1 profoundly compromised responsiveness to LIF.
Under such conditions the absorptive capacity and intestinal adaptation is profoundly compromised and often necessitates total parenteral nutrition.
However, insulin kinetics, such as the ability of the pancreatic β-cell to release adequate hormone in phase with rising glycemia, are profoundly compromised.
These results came as no surprise, while more intriguingly, Treg cell expansion through B-cell-dependent mechanisms [ 69] leads to profoundly compromised T-cell responses [ 70].
In particular, we showed that silencing MMP2 expression all but eliminated gelatinase activity in AF cells and profoundly compromised their ability to remodel collagen matrices.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com