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In nearly 65 years of a profoundly close and loving marriage, both spoke often of the depth of their mutual love, of their support for each other and of how the independence of their respective careers enabled them to give each other the space that they needed to succeed individually and grow and mature together.
This is because of your physical need to feel a profoundly close connection to your partner.
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It wasn't just Gielgud bringing "The Tempest" to a profoundly moving close.
Having guided the huge span of the first movement faultlessly to its shattering climax and profoundly unsettling close, Haitink made the two scherzos that follow all the more menacing by exerting restraint and keeping them rhythmically tight.
Yet the effect is profoundly unsettling – the closest thing to a drugged dream-state that live pop music has to offer.
The nucleoli of PARP-1 and PARG mutants reveal profoundly condensed areas positioned close to nuclear lamina, which may affect nucleolar functions such as rRNA processing and ribosome biogenesis.
His book is about the profoundly ambivalent experience of playing them — close readings (close playings?) mostly of big-budget action and science fiction titles for consoles like the Xbox and PlayStation.
Following national service in the RAF, he read English at Jesus College, Cambridge, where he was profoundly influenced by FR Leavis's close reading of texts and belief in the ethical value of intensive engagement with works of art.
But even more profoundly, he helped me feel close to my history as a gay person and for that, I am forever grateful".
"You have altered my life so profoundly that many of my closest friends forget just how emotionally withdrawn I was before I met you".
And it argued from weathered experience that anyone suffering from depression must not, whatever happens, give up – indeed, its closing pages are profoundly redemptive, offering hope and guidance to anyone who has been affected by the condition.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com