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I found this knowledge profoundly challenging.
Change is profoundly challenging.
I think the changing role of the teacher is profoundly challenging.
Absolving in tone yet profoundly challenging, the president took the nation to the mountaintop.
Those in my profession work very hard in profoundly challenging circumstances to do our best for our patients; when losses like this do occur, we are all devastated.
It is not profoundly challenging to design a computer that can beat a human at a rule-based game like chess; a logical machine does logic well.
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True, downtown Dayton is profoundly challenged.
Yet seeing those players stand up still profoundly challenged my preconceptions.
Both issues profoundly challenge the tenets by which Japan has been ruled in recent decades.
Meanwhile, the European banking system is profoundly challenged and in the US wages have not grown for a generation".
And in a publishing landscape filled with the lame and infirm, weeklies are the most profoundly challenged.
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CEO of Professional Science Editing for Scientists @ prosciediting.com