Not even the miraculous scientific achievements of the twentieth century have affected human health and development as profoundly as has the ready availability of clean water.
By the time he returned to Leningrad, in late 1965, Brodsky was world famous, and had developed profoundly as a poet.
But my illness has changed me profoundly as a physician.
That will change finance as profoundly as any regulator has.
Will it change our picture of the universe as profoundly as Hubble?
But none of them have the power to move us as profoundly as "home".
To affect us and alter us, as profoundly as real people and things do.
And I think teaching has lived as profoundly as journalism in my background.
Few films capture life's bittersweet rush and tumble so completely, so profoundly as Jules et Jim.
The accumulation of incidents changed the capital's psyche as profoundly as 9/11 in New York.
Television began to change, rapidly and profoundly, as power shifted from corporate offices to increasingly fickle viewers.
