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The malignancy is profoundly active and responds poorly to any form of therapy.
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The finding that only a small fraction of IDE molecules are normally active at any one time may also help to account for IDE's ability to be profoundly activated by multiple ligands [23], [30], [31], [35].
On the other hand, B. anthracis vegetative bacteria profoundly expand during active infection, achieving 108 109 organisms per milliliter of blood; [2], [3].
IgG profoundly accumulated in early active lesions (Fig. 3O).
As the Pentagon has increasingly tapped the National Guard and Reserves for active duty, it has profoundly affected the armed services, their budgets and military operations around the world.
At about 3500 3000 yr BP, a particularly active meteo-marine regime profoundly affected the depositional dynamics.
Profoundly committed to education, he was an active volunteer for Andover, the USMMA, Yale, and Sweet Briar College, where he was past president of the Board of Trustees.
Highly active antiretroviral therapy (HAART) has profoundly transformed the incidence and prognosis of IAI in patients with HIV and AIDS.
However, even if the problem is far from a definitive solution, highly active antiretroviral therapy (HAART) has profoundly changed the natural history of HIV infection dramatically reducing AIDS- (acquired immune deficiency syndrome-) related morbidity and mortality [ 1].
These activities affected MIT profoundly.
Protein kinase CK2 is a profoundly conserved, perpetually expressed, messenger independent and constitutively (presumably) active serine or threonine kinase that can use ATP as well as GTP as co-substrate localized in cell nucleus and cytoplasm.
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CEO of Professional Science Editing for Scientists @ prosciediting.com