Sentence examples for profound variability from inspiring English sources

Nonlinear dynamics, profound variability, and uncertainty inside the complex human body cause critical challenges for controlled drug delivery.

Profound variability occurs in the third hypervariable (CDR3) segments of light and heavy chains even within antibodies of the same ostensible specificity.

Given the profound variability of biological processes TRS uses very short time windows which are shifted beat by beat allowing for temporal resolution of frequency and amplitude [15], [16], [17], [18].

The cellular response to glucocorticoids displays profound variability both in magnitude and in specificity of action.

The cellular response to glucocorticoids displays profound variability both in magnitude and in specificity of action [ 2, 11].

Profound variability has been observed in IFNAR1-driven tissue recruitment of myeloid cells in different diseases, implying that pathogen-specific signatures shape downstream innate immune responses.

The present data indicates profound pharmacokinetic variability of linezolid during CVVHF and CVVHDF.

Cell proliferation in human bone marrow and gut has likewise been shown to exhibit profound circadian variability [ 29, 30].

A profound inter-individual variability is seen for both the progression of chronic hepatitis C-associated disease as well as treatment outcome.

Spatially, vertical variations in precipitation seasonality exert profound influences on isotopic variability for stream waters.

The use of animal models has the prospect of minimizing some of the profound genetic and environmental variability often encountered in human proteome studies where unbiased control samples are often difficult to obtain [16].