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MERS and SARS also pose potentially profound threats.
By contrast, "periods of protracted peace have repeatedly presented the most profound threats".
The central bankers have succeeded at getting us past a set of profound threats to human well-being, for now at least.
Already, African lion in many African countries are experiencing profound threats, in the shape of poaching, human-lion conflict, and habitat encroachment.
"The highly specialised rainforest biodiversity in many protected areas is facing profound threats as their surrounding lands are being hit by a tidal wave of logging, fires and intensive human land-use," he said.
Having been the first medical specialty to endorse the digital revolution, it is also the first to face the amazing opportunities, but also the profound threats, from artificial intelligence [1].
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Critics say the databases may therefore also represent a profound threat to privacy.
A democratic, European Ukraine moving out from under its influence would be a profound threat to Mr Putin's Russia.
The cloud represents a profound threat to Microsoft's traditional business of selling software that people install on their machines.
Scientific management, moreover, demanded strict supervisory control over the workplace and hence posed a profound threat to customary patterns of workers' autonomy in the labour process.
Similarly Lincoln and the Republicans believed that the slaveholders posed a profound threat to the nation's democratic institutions and values.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com