Sentence examples for profound stage from inspiring English sources

There is probably an affecting and profound stage narrative within this dense, crowded production.

"This is the next and the more profound stage of the battle for civil rights.

That this is a profound stage of childhood that I'm not ready for him to leave?

Although not a profound stage work on the order of, say, the best of Tennessee Williams or Edward Albee, the play reveals telling insights into the human condition.

Therefore, if disease progresses into the more profound stage with BACE1 elevation, deleting a single BACE1 allele is not sufficient to block the BACE1-elevating mechanisms.

In conclusion, the results presented here demonstrate that the same degree of β-secretase suppression (e.g., 50% by BACE1+/− deletion) becomes less efficacious and eventually ineffective in reducing Aβ/C99 accumulation and rescuing cholinergic neurodegeneration or memory deficits in 5XFAD mice as disease progresses into the more profound stage that is accompanied by BACE1 upregulation.

In the final celebratory ensemble, the characters toss away their costumes, and everyone joins together in everyday wear, a profound staging touch.

Indeed: there's no bigger contrast between what Kosky did for Rameau and his Magic Flute, which is a joyous yet profound staging in which animation takes centre stage.

Our findings also suggest that antidementia drugs may benefit patients even when given in advanced or profound stages of AD.

On the basis of data from biomarkers, AD can be reconceptualized as a progressive disorder that advances from biological changes in the brain with no accompanying cognitive abnormalities, to a state of memory impairment with biomarker abnormalities indicative of AD, to mild, moderate, severe, and profound stages of AD dementia.

He was a Colin Kaepernick of his time, only on a more profound world stage and with greater implications.