These analyses show that the AMPAR proteome is dynamic in both space and time: AMPARs exhibit profound region specificity in their architecture and the constituents building their core and periphery.
Profound species specificity has been widely shown for the anticoagulant/antithrombotic activity of APC [ 18- 22].
In other situations, there is evidence that PPARα-dependent effects exhibit profound species specificity, with rodents being very sensitive and humans being much less sensitive, if not refractory (e.g., Klaunig et al. 2003).
It was cognate with a new specificity, a profound concern with the precise details of perceived phenomena, that took hold across the arts and the literary and historical disciplines and would have profound effects on the rise of modern science.
New Brunswick, NJ, Transaction Publishers, pp. 203 220), which, despite their locational and topical specificity, offer profound potential for broader urban social change.
Our results have shown that such positions as well as some other polymorphic positions are important both in recognition and anchoring effects, having profound implications in the specificity of this allele.
Such differences have a profound impact on host specificity.
Even a small sequence variation can have a profound impact on targeting specificity, especially when the new sequence comes with a different seed region.
These post-translational modifications undoubtedly have a profound influence on the specificity of PARP-1 for its substrate proteins and interaction partners and may also influence the DNA binding affinity and conformational dynamics of PARP-1 (e.g., interconversion of PARP-1 structures shown in Figures 3 and 4).
Detailed examination of E13 and E14 rat embryos shows that the loss of Hmx1 expression in dumbo embryos is not uniform, but instead shows marked regional specificity, with profound loss in CM in the branchial arches and relative sparing of expression in regions of Hmx1 expression in the parietal region adjacent to the hindbrain.
