Considering the profound requirement of NGF for nonpeptidergic nociceptor gene expression, one possibility is that NGF promotes expression of Runx1, Cbfb, or both, thereby enabling Runx1/CBFβ complex formation, stabilization and function, and thus initiation of the nonpeptidergic nociceptor fate.
Water is a fundamental requirement for life.
A fundamental requirement for collaboration is communication.
There may therefore be a profound species difference in the requirement for tankyrase during mitosis.
We know the system is complex and if we can't navigate it, how can we expect others to?" Profound impact The Care Act, with its requirement for carers to be assessed for support, is an important step forward.
In its most severe form, β-thalassemia major, affected patients have profound secondary iron overload largely due the requirement for chronic red blood cell transfusional support.
The requirement for data sharing had profound implications for the relationships and values within the MalariaGEN research culture and required researchers to engage critically both with their own commitment to data sharing and their sense of responsibility to research communities.
P. gingivalis has an essential requirement for haem [3] which has a profound influence on its virulence properties [4], [5].
Avoiding profound hypothermia is associated with a reduction in bypass times, postoperative bleeding, requirement for blood transfusions in the clinical setting, and a reduction in endothelial cell dysfunction and neuronal apoptosis in the experimental setting [ 33, 73– 73].
Accurate diagnosis of a severe-to-profound bilateral sensorineural hearing loss remains the primary and most basic requirement for implantation [ 19].
