Sentence examples for profound regeneration from inspiring English sources

Since Smad4 RNAi) causes a profound regeneration defect, the apoptotic increase could be secondary to this defect.

In 2006, Lesurtel et al. identified platelets as the primary source of 5-HT in the regenerating liver and demonstrated profound impairment of hepatocyte regeneration in Thp1−/− mice recovery from PHx [32].

The discovery of the interaction between the nervous and the immune system has, for example changed our view on the development of inflammatory diseases, while the cloning of genes encoding different trophic factors has boosted studies revealing profound changes in the regeneration of neurons, and induction of changes in phenotype.

A study of β-cell regeneration following profound β-cell ablation also found evidence of α- to β-cell transdifferentiation, but the efficiency of conversion was low.

However, deletion of the laminin γ1 subunit in the peripheral nerve (thus ablating all functional laminin trimers) causes a profound reduction of the regeneration of spinal motoneurons after sciatic nerve crush [ 69].

Retinoids also have profound effects on amphibian limb regeneration.

This procedure provokes initial profound muscle degeneration, followed by regeneration [21], [25].

The understanding of homeostatic regulation of normal epithelial tissue regeneration could have profound implications for developing therapies to target key growth promoting pathways.

Taken altogether, our results demonstrate that BM-derived cells were strategically involved in CCR2-dependent intramuscular events that had a profound effect on skeletal muscle regeneration.

Our future efforts will be focused on developing an in-depth understanding of the cross talk between NF- κB and β-catenin signaling, which could have a profound impact on improving bone regeneration and repair in inflammatory microenvironments.

It is thus conceivable that the positive effect of hAMSCs in angiogenesis should have a profound meaning in bone tissue regeneration and other clinic applications, even though many challenges should be conquered.