A profound nucleus volume deficit (>40%) was observed in the nucleus accumbens, thalamus, and claustrum; very severe (>30%) in Purkinje cells; severe (<30%) in the amygdala, putamen, entorhinal cortex, and MBC; moderate (<20%) in the globus pallidus, parvocellular lateral geniculate nucleus, Ammon's horn, and inferior olive; and mild (<10%) in the substantia nigra.
Loss of Drosophila Usp36 (dUsp36) accompanied the accumulation of aggregated histone H2B (known substrate of Usp36) in cell nuclei, reflecting profound defects of chromatin structure in dUsp36 mutant cells.
The particles given off during the decay process are part of a profound fundamental change in the nucleus.
Excitotoxic lesions of the pedunculopontine tegmental nucleus (PPTg) produce profound deficits in performance of this task that are not accounted for by motor impairment.
Male offspring exhibited higher energy expenditure as mirrored by increased hypothalamic UCP-2 and liver AdipoR1/R2 expression, and a profound change in the arcuate nucleus astrocytic organization.
While 3′-end processing takes place in nucleus, it has profound effects on gene expression regulation, including transcription termination, terminal intron removal, mRNA export, translation initiation, and mRNA stability [ 2- 5].
Here, we report on profound chromatin reorganization in fibroblast nuclei by chaetocin, a thiodioxopiperazine metabolite.
Mounting evidence suggests that mechanical forces within the nucleus may have an equally profound effect on nuclear structure and yet remain relatively enigmatic (Buster et al. 2013; George et al. 2014).
The profound neuron loss with age to the nucleus basalis [ 49], the gateway module for new learning in the brain, may help to ensure that a mature organism cannot reprogram its tried and true behaviors with new, untested learning.
Megakaryopoesis shows profound and characteristic dysplasias with either separated multiple nuclei, hypolobulation, microkaryocytes, and most characteristically monolobulated megakaryocytes with a round nucleus.
Although research in this field is in its infancy, identifying alterations in the nucleus in neurodegenerative disease has potentially profound implications for elucidating the pathogenesis of these disorders.
