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The medical implications of the findings could be profound, notes human geneticist Judy Cho of the Yale School of Medicine, who wasn't involved in the research.
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As you can imagine, I wrote some pretty profound iPhone notes during the experience: .
"As the entire banking value chain is being challenged, the payments sector has seen the most profound transformation," noted Sebastian Siemiatkowski, Klarna's co-founder and CEO, in a statement.
Considering the range of profound deficits noted across subjects, it was notable that four of the 55 (7%) subjects in the group were found to be normal at onset and all of these remained normal throughout the study.
And although the effect of TGF-β deletion on TFH cell formation and function is profound, as noted by the reviewers in point 6 below, the functional defects may be even stronger than the phenotypic defects.
With profound sorrow Temple Am Echad notes the passing of our cherished former Rabbi.
"As with the work of any profound artist," Robert Towers notes, "an element of the mysterious – of the unspoken, the unacknowledged – hangs like a shining mist over all that has been consciously intended and consciously achieved".
The siblings Lana and Andy Wachowski, talking about "Cloud Atlas," may actually have touched something profound when they noted, as she put it, that the book, "Cloud Atlas," "affects your brain".
But even liberals expressed mixed feelings about Holder's packed tenure, noting profound disagreements on national security issues among praise for his work on sentencing reform and civil liberties.
In one sweeping column, he hailed the 1704 capture of Gibraltar "as an opening chapter in democracy's vindication", noted "profound echoes" with today's struggles against autocrats in the Muslim world, and even suggested that "far-sighted" Spaniards might learn to see Britain's Iberian outpost as the rock on which western success was built.
Studies of driver behavior have noted profound perceptual changes and associated behavioral consequences in older drivers (Owsley, 2011; Sekuler, Hutman, & Owsley, 1980).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com