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'profound negative influence' is correct and usable in written English.
You can use it when you want to describe something that has had a deep and significant negative influence, such as: The recession had a profound negative influence on the mental health of many people.
Exact(2)
Our results showed that atrazine exposure had a profound negative influence on selected indices and also on histological changes of common carp.
Taken together, the findings from this cohort were dramatic and suggested that MRI BME in early RA has a profound negative influence upon outcome, both within the bone (development of XR erosions), cartilage (JSN), and tendons and in terms of overall physical function.
Similar(58)
Chronic illness and chronic pain can have profound negative effects on relationship and sexual satisfaction, yet the influence of migraine on sexuality has not been previously evaluated.
Working schedules involving long working hours also seem to have a negative influence on caregivers' decision-making capabilities, which may have a profound impact on patients' safety [ 5, 6].
"American support for Palestinian statehood is therefore crucial, and a veto will have profound negative consequences.
Treating APIs as copyrightable would have a profound negative impact on interoperability, and, therefore, innovation.
a positive influence, a negative influence.
Here, we discuss pornography's negative influence on your smartphone.
Of course, the negative influences of globalization abound.
Third, subtract the negative influences.
But I chose to draw upon the negative influences.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com