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"There can be no doubt that a project of this scale and scope, in an area as remote and protected as Lamu, cannot help but have profound negative impacts on the heritage," said a 2015 report on the area from Unesco's World Heritage Committee.
Depression is prevalent in new mothers and has been shown to have profound negative impacts on parenting, maternal life course, and child development.
Forest ecosystem modifications perpetrated profound negative impacts on sustainable food production, freshwater availability, species diversity and richness, climate, and human well-being (Overmars and Verburg 2005 and Potter et al. 2007).
There is growing evidence that mesquite invasions in South Africa are having profound negative impacts on biodiversity (Dean et al. 2002; Steenkamp and Chown 1996; Schachtschneider and February 2013; Shackleton et al. 2015a, 2015b), ecosystem services (Ndhlovu et al. 2011; Dzikiti et al. 2013) and local livelihoods and economies (Wise et al. 2012; Shackleton et al. 2015c).
The overwhelming consensus among scientists is that those emissions are causing global temperatures to rise and are transforming the natural environment in ways that already are having profound negative impacts on plant and animal life.
The loss of prairie dogs had profound negative impacts on the maintenance of grasslands and the expansion of shrublands.
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The report's recommendations include: The government should take action to discourage schools from setting children by ability, particularly at primary level, because of evidence that it could have a profound negative impact on pupils' future social mobility.
"The global credit crisis has had a profound negative impact on what was already a weakening and very fragile global economy," Jeffrey M. Fettig, the chairman and chief executive, said in a statement.
"We believe that the Arctic refuge should be preserved and that the budgetary effects of oil leases in the refuge are incidental when considering the profound negative impact of drilling in the Arctic refuge".
It is the intensity of the anxiety experienced, the wider range of feared social situations, and the profound negative impact on functioning that sets SAD apart from milder instances of social apprehension.
The $5.6bn acquisition of the Wall Street Journal in 2007, at a steep premium to its market value, happened despite the recognition by News Corp's executives that the deal would have a profound negative impact on News Corp's shares – and despite the fact that the Journal would shortly be worth only a fraction of what the company paid for it.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com