Sentence examples for profound negative affect from inspiring English sources

A number of researchers have noted that the stigma attached to edentulism can have a profound negative affect on mental well-being.

This is consistent with the findings for the CAPN3 null-alleles patients, where the absence of calpain 3 as seen in patients with two CAPN3 null-alleles has a profound negative impact on the regenerative response, so severely affected patients with LGMD2A with the highest need for regeneration have the most impeded response.

It is, after all, their ranks that would be expanded, and such a thoughtful, intelligent, and increasingly well-informed crowd is unlikely to sit by as their betters make decisions that will have a profound (and possibly negative) affect on their futures.

Although the economic costs of suicide in Indigenous populations has not been quantified, the profound negative impact of suicide on the social and emotional wellbeing and psychological functioning of affected Indigenous individuals, families and communities [ 7, 15] strongly suggests they are likely to be high and accumulate over a lifetime.

Chronic pain, defined as pain of at least moderate severity, and present every day or almost every day for at least six months, affects one adult in five in Europe [ 1], and has a profound negative impact on quality of life [ 2].

Treating APIs as copyrightable would have a profound negative impact on interoperability, and, therefore, innovation.

Lymphedema following treatment for breast cancer can be an irreversible condition with a profound negative impact on quality of life.

Symptoms have a profound negative impact on quality of life and are associated with increased health care utilization.

Our results provide evidence for a profound negative impact of diabetes on workforce participation in France.

Extreme fatigue is widespread among new mothers and can have a profound negative impact on functioning.

In particular, the structure provides an explanation for the observations that, in addition to mutations affecting the conserved cysteine ligands, alterations in the sequence between the two zinc-binding modules or C-terminal to Zn-2 have a profound negative impact on CTD function (Budd and Campbell, 1993; Navas et al, 1995; Dua et al, 1998, 1999).