Sentence examples for profound mutations from inspiring English sources

However, it has been reported that the laboratory strains of HCMV experience profound mutations during replication in human fibroblast cells [29], [34], [35], [36], [43].

Very rarely, he argued, such profound mutations could be beneficial and allow the organism to rapidly adapt to a new mode of life.

For the new generation, the ideal of success is a job with a regular salary that alienates them from their pastoralist upbringing, which has already brought about a profound mutation in Soqotra's pastoral way of life.

To date, however, there have been difficulties in producing transgenic mice carrying profound pathogenic mtDNA mutations (5) (R.N.L., personal observation), and it has not been possible to completely recapitulate, in mice, all the symptoms of any form of neuronal disorder associated with mtDNA defects.

The interplay of high-fidelity and low-fidelity DNA polymerases is expected to have a profound impact on mutation rates and spectra, and conversely changes in mutagenesis can provide clues about the nature of the competition between DNA polymerases.

Profound differences in mutation frequency were observed between various histopathological subtypes of tumors.

During that time, recombination between strains happens which has a much more profound effect than mutation or recombination with the same infecting strain.

However, in some cases, enzymatic activity does not adequately differentiate partial deficiency from heterozygosity for profound deficiency; therefore, mutation analysis is necessary to confirm the diagnosis (Wolf 2010).

Changes in epigenetic marks can be as profound as DNA sequence mutations, but unlike DNA mutations, epigenetic marks are reversible and responsive to the environment (Baccarelli and Bollati 2009).

As previously noted the P19A mutation had the most profound destabilizing effect; the other mutations were only slightly destabilizing.

The p.D444H mutation alone is a "milder" mutation and in combination with a mutation for profound BD on the other allele results in partial BD.