Various major body changes may precede the emission of gametes, the two most profound being epitoky (maturation into a modified, fertile form) and stolonization (the development of stemlike growths).
When miR-221 and miR-222 were expressed in myotubes undergoing maturation, a profound alteration of myofibrillar organization was observed.
Consistent with the key role of eDNA, the expression and extracellular activity of the S. aureus thermostable nuclease has profound effects on biofilm maturation [6], [8].
As shown in Figure 5A, both the graS mutant (37 C9) and the imp mutant (60 G7) displayed profound defects in biofilm maturation in the flow cell.
Despite the lack of effect on platelet number, JAK2 V617F expression caused profound abnormalities of megakaryocyte maturation and platelet function, manifested by small megakaryocytes, abnormal mitoses during proplatelet formation, and a markedly prolonged tail bleeding time.
Complete rescue of NBD1 folding appeared, in spite of the profound effect on CFTR maturation, insufficient for full functional rescue of the CFTR molecule, suggesting that the ΔF508 NBD1 still was hampered in some domain-domain interactions.
Silencing of BIG1 expression induces a minor disruption of the Golgi complex, described as a looser Golgi, and a profound defect in the maturation of β1-integrin followed by a subsequent defect in the spreading of the cells [20].
This stimulus has a profound effect on the maturation of mucosa associated lymphatic tissues (e.g., Peyer's patches) and other lymphoid tissues [ 39, 40].
However, although this holds at the gross anatomic level, at the fine structure level, this distinction tends to break down as the local environment exerts a profound influence on synaptic maturation.
However, a wealth of evidence from nonhuman animal studies indicates that the hormonal events of puberty exert profound effects on brain maturation and behavior [Cahill, 2006; Sisk and Foster, 2004; Spear, 2000].
