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The pontificate of John Paul II, one of the longest in history, left a profound mark on the church and the papacy.
Nicholas's short but eventful reign left a profound mark on the medieval church and papacy.
Far from it: in the second quarter of this year they put almost $7 billion into Silicon Valley technology companies a new high.A softer touchMost agree that the Internet boom has left a profound mark on the Valley.
The country was ready for Ehrlich's message when he published "The Population Bomb" in 1968, but his tremendous success in turn left a profound mark on public thinking about environmental problems.
It is rarely, however, that a novelist makes a profound mark on a national language, as opposed to a regional dialect (to which, by using it for a literary end, he may impart a fresh dignity).
"Ruth Cardoso modernized the role of the president's wife and left a profound mark on Brazilian social policy," Miriam Leitão, a Brazilian newspaper columnist, wrote in a tribute last week.
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"He's left a deep and profound mark [on Brazilian jiu-jitsu]," Peter Maguire, an old friend and former training partner, says.
Their duration alone is exceptional, as is their emphasis on the physical struggle, the passionate and uninhibited athleticism of sex, the profound marking of the characters' souls by their sexual relationship.
His three years there had left a profound mark.
For the human beings who passed through it, the stoneyard left a profound mark.
None of the people I spoke to had any doubt that humans were leaving a profound and lasting mark on our planet's geology.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com