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One of the intriguing aspects of the Powell-Blair relationship is the combination of unswerving loyalty with flashes of profound irritation.
Renzi has never been one to toe the PD line: when he stood in primaries for mayor, it was to the profound irritation of party elders, who had told him to wait his turn.
But it is also a profound irritation to Prague's Jewish leaders that Rabbi Loew's legacy has been hijacked by a powerful dunce whom the Talmud characterizes as a "fool".
Berlusconi recounted how he had played an instrumental role in the Spring in persuading a reluctant Erdogan to accept Danish PM Rasmussen as the new NATO Secretary General, overcoming the Turkish President's profound irritation at Rasmussen for not silencing Kurdish language radio stations despite numerous requests.
Although she was a respectable driver, she hated to operate anything mechanical more complicated than a safety pin: folding lawn chairs were a source of profound irritation to her; she had never learned to ride a bicycle or use a typewriter; she fished with a pole.
The offer of a donation made in terms of a percentage of proceeds has become a familiar pitch, and it is one that arouses the profound irritation of people like Professor Einstein and the economist Patrick M. Rooney, monitors of the philanthropic world, precisely because the phrase itself is subjective and vague.
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The exit polls did not shed much light on the California voters' feelings, except their profound sense of irritation.
Yes, there are mild irritations along with profound qualms: American dependence on the automobile, capital punishment, puritanical views, to name a few.
What must it be like to be Paulina, with her constant irritation and discontent — signs of a profound insecurity that she can barely keep in check?
What is most striking to Brazilians reading Bishop's poems now, Mr. Jabor said, is her "Calvinist irritation with our shortcomings and endemic problems, mixed with a profound compassion for our suffering and an uncommon love for the fragility of our people that is rarely found in Brazilian poets".
In addition, with incremental dose often an individual "reaction threshold" is observed, showing profound reactions at the injection site within 24 hours, in rare cases also systemic reactions (irritation, pain, and an increase of body temperature).
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