Sentence examples for profound involvement of from inspiring English sources

The profound involvement of the activin axis in liver biology and in the pathogenesis of severe hepatic diseases suggests activin as potential target for therapeutic interventions.

Furthermore, several studies suggest that iNOS induction is involved in cytokine-induced insulin resistance, given that increased iNOS expression is related to an impaired insulin-stimulated glucose uptake [68] revealing a profound involvement of iNOS in both immunologic and metabolic systems.

Our data indicate an early and profound involvement of glial cells in pathogenesis of MLIV, a disease traditionally viewed as being "neuronal", and provide new clues to the development of therapies for this devastating disorder.

As Rem says of his own working method, he maintains "at the same time a profound involvement and a profound distance from issues, so that you can … stand outside to be able to judge".

Protest is often people's first and most profound involvement with politics.

As presented here, "Rain" explores the profound spiritual involvement of six southwestern cultures -- the Hopi, Navajo, Apache and Tohono O'odham of Arizona and the Zuni and Rio Grande Pueblos of New Mexico -- with the powerful but sparse resource that makes life and growth possible.

The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding of the involvement of these proteins in colorectal tumour progression.

Such an evaluation may provide a more profound understanding of the involvement of these angiogenic proteins in colorectal tumour progression, particularly considering the known differences in binding affinities of VEGF ligands to their receptors.

Those years witnessed the extension to the states of nine of the specifics of the Bill of Rights; decisions which have had a profound impact on American life, requiring the deep involvement of state courts in the application of federal law.

The cases demonstrated severe failure to thrive and in addition to commonly described features profound proteinuria and albuminuria, together with hypoalbuminaemia, suggesting glomerular involvement of this syndrome.

Nearly 70-80% of patients have involvement of the regional lymph nodes which has a profound influence on survival [ 2, 3].