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It was a profound insult that he had felt in life.
"It is a profound insult to the Native American people," said Wickman, who contends that support for the symbols among tribe members is not universal.
That is a profound insult to the many lawyers who worked tirelessly not to help Al Qaeda, but to defend our values and our Constitution.
Perhaps Roosevelt's most profound insult was targeted at Democratic President Woodrow Wilson.
As such, it is a profound insult to the intelligence of students and at variance with the basic concept and purpose of a university".
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And there can be few more profound insults than to assert that someone is unfit to be a parent.
We have always had mixed feelings about the mental and physical decline that comes with living longer, but for women, especially, who in America outlive men by six years on average (the nerve of us!), visible signs of aging are treated as profound insults to one's physical and psychological well-being.
Bilateral facet dislocation is the most severe injury of the flexion-distraction spectrum, which usually results in profound neural insult [27].
Hypothermic treatment is recognized as a neuroprotective treatment after a profound neonatal insult.
Yet many of the ICU controls may have similarly suffered profound inflammatory insults, and so some of the potential mechanisms for poor long-term health and quality of life may have been present in both the cases and the controls.
There is a darkness about Trump that negates that sort of humor: a folly so bewildering, an incompetence so profound that no insult could plumb its depths.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com