1– 5 This diversity can have profound effects on infection and disease progression, transmission dynamics, and clinical patient management.
Unfortunately, patients who received atacicept had profound hypogammaglobulinemia and infection [ 41].
Longer-term temporal dependencies can be caused by repeated admissions of the same patients, and these readmissions can have profound implications for infection dynamics in health care settings (4– 7).
In selected patients with a history of life-threatening infections or profound immunodeficiency or persistent opportunistic infections, strategies to increase the circulating CD4 lymphocytes could be considered.
These observations underscore the profound impact of infections on progression and severity of CF lung disease.
LSU-Lb to disrupt sexual reproduction in fleas, as well as other arthropod vectors, has profound implications for infections disease research and arthropod pest management.
These discoveries are of profound significance because infections are often avoidable (through vaccinations for example) or treatable; the associated somatic illnesses could then be avoidable.
Thus Rac expression plays a profound role in infection-triggered arthritis and demonstrates a bimodal influence on the disease process, exacerabating acute joint inflammation but controlling chronic arthritis.
X-linked agammaglobulinemia (XLA, OMIM 300300), first described by Bruton in 1952, is a fully penetrant X-linked recessive disorder characterized by recurrent bacterial infections, profound hypogammaglobulinemia and marked decrease in the number of B cells in the presence or absence of positive family history.
Moreover, Listeria monocytogenes has a profound predilection for disseminated infection during pregnancy [ 2– 4] which is attributable to the induction of fetal-placental infection triggering stillbirth, spontaneous abortion, premature delivery, and neonatal infection [ 5].
