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Database search using ProFound identified PKD1L2, as expected, but additionally the enzyme fatty acid synthase (FASN) was identified as the top scorer.
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We have this on no less an authority than that of Bob Diamond, chief executive of the whole Barclays group and head of the investment banking unit when the profound failings identified by the FSA and US regulators occurred.
In line with the studies of Hibbard et al [ 7, 8, 18], we hypothesized that all health plans would improve their performance but that the changes over the years would be more profound for identified areas of improvement and for health plans with an inferior performance at the first measurement.
Luria catalogues various difficulties that S. experienced navigating everyday life, linking them to profound deficits he identified in S.'s ability to conceive the world in abstract terms.
This cytokine is usually considered as immunoregulatory or immunosuppressive depending on the context, but research has identified profound effects of IL-10 expression early in infection [54].
Histological sections and global evaluation of gene expression after administration of clenbuterol in pigs identified profound changes in adipose cells.
This study identified profound deficiencies in the system functions of patient care, staffing and the management of the Medical Department of KCH.
We identified profound reductions in the neuritic complexity in neurons derived from SPG11 patients compared with controls (Fig. 3A and B).
Mutant analysis of Sod1 and Sod2 in Drosophila have identified profound effects on lifespan, free radical damage and sensitivity, and age-associated neurological disorders [ 28, 29].
They removed at least one tRNA and several subunits of complex I, which is consistent with the profound biochemical defect identified in all examined tissues.
We identified profound and hyperacute TNF-induced mortality, in sharp contrast to the previously described resistance of MK2-deficient mice to LPS/ d-Gal-induced hepatitis [ 6] and similar results we obtained here in an endotoxic shock model.
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