The European commission's ruling would have a "profound and harmful effect" on investment and job creation in Europe, he said.
In a letter to customers, Apple's chief executive, Tim Cook, claimed the ruling could deal a blow to big companies investing in Europe: "Beyond the obvious targeting of Apple, the most profound and harmful effect of this ruling will be on investment and job creation in Europe.
It will have a profound and harmful effect on investment and job creation in Europe.
Beyond the obvious targeting of Apple, the most profound and harmful effect of this ruling will be on investment and job creation in Europe.
But the Commission is now calling to retroactively change those rules, "Beyond the obvious targeting of Apple, the most profound and harmful effect of this ruling will be on investment and job creation in Europe.
But within the past decade, research has shown that body fat is potent stuff: a highly active tissue that secretes hormones and other substances with profound and sometimes harmful effects on metabolism, weight and overall health.
In recent studies, evidence has shown that fat tissue -- far from being a dormant storage depot for surplus calories -- is actually an active organ that sends chemical signals to other parts of the body with profound and sometimes harmful effects to your body.
"This issue has the potential of being harmful in more profound ways than any issue we have faced".
OF course, our national habit of eating fast food on the run is also a symptom of a larger problem, one that has even more profound implications for heart disease than a harmful diet or lack of exercise does.
Understanding urban soil geochemistry is a challenging task because of the complicated layering of the urban landscape and the profound impact of large cities on the chemical dispersion of harmful trace elements.
