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First, these regimens may be optimised with the goals of reducing the incidence of profound grade 4 thrombocytopenia and neutropenia and of limiting the total dose of bleomycin, especially in patients with multiple lung metastases (for example those with the 'choriocarcinoma syndrome').
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Profound (≥ grade 3) non-dose-limiting lymphocytopenia was observed in 5 patients (at a dose ≥ 2.0 mg/m in 4 patients).
But, she said, by eighth grade profound divisions had already been cemented.
Today, the law requires schools to do something simple, yet profound: Educate students to grade level.
There is no academic-driven simulator that is freely accessible to every student and combines high immersion grade with a profound amount of medical content.
A surprisingly profound game.
Except maybe for the last one, these are pretty profound questions, way above my pay grade.
Grade 4 is manifested by profound shock with undetectable blood pressure or pulse.
Three patients developed uncontrollable profound bleeding manifestations and one patient developed grade 4 hepatic encephalopathy prior to death.
Strong experimental evidence indicates that S100A8/A9 overexpression in hepatocytes is associated with liver carcinogenesis as epidemiological studies showed a profound correlation of both proteins with high grade hepatocellular carcinoma in humans [ 20].
Its symptoms, which include weakness, profound lassitude, difficulty concentrating, insomnia and low-grade fever, remain equally unexplained.
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CEO of Professional Science Editing for Scientists @ prosciediting.com