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The uncertainty of the process is a profound failing of the patent system.
His slip-up is symptomatic of Ukip's most profound failing: they are a one-policy party.
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For all of Yeltsin's profound failings and the reflexes he had developed as a lifelong Communist apparatchik, he was rarely hostile to the press.
We have this on no less an authority than that of Bob Diamond, chief executive of the whole Barclays group and head of the investment banking unit when the profound failings identified by the FSA and US regulators occurred.
If, as is likely, Liberia receives the all-clear after going 42 days without any new cases of Ebola, the WHO will announce the end of a two-year epidemic that has killed more than 11,000 people, ravaged communities in three west African countries, and revealed profound failings in the international community's response.
MI5 today expressed "profound regret" for failing to prevent the 7/7 bombings.
The revelation was the culmination of a compelling day in court, in which a top spy said MI5 felt "profound regret" over failing to prevent the bombings.
Circulating unstoppably online is an entire shadow oeuvre, generally trying, and failing, to sound profound, and breathing of passion.
For us, the stress of war was as much professional as profound, the fear of failing as gripping at times as the fear of getting hurt.
These are profound judicial failings, falling short not only of the standards of the Eichmann trial but also of the requirements of Bangladeshi law.
Notably, the implantation of isolated populations of cells in failing myocardium has a profound and consistent anti-remodeling effect that limits the progression to CHF.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com