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"While you may consider this some profound experiment on the path and speed of oceanic currents, I have another name for it," the letter read, "litter".
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Even the most seemingly profound experiments can be a little underwhelming when looked at in detail.
In a time course experiment a profound repression of six nuclear receptor genes characterized the initiation of differentiation and a time lag was observed for up-regulated nuclear receptor genes.
The sensitivity of the liver to endotoxemia is emphasized by the presence of hepatic mitochondrial dysfunction even in those pigs surviving to the end of the experiment without profound hypotension.
Hen's experiments have profound implications for psychiatry and psychology.
Transcriptional profiling experiments uncovered profound molecular changes in SRF-null E17.5 epidermis and revealed that many previously identified SRF target CArG box-containing genes were markedly upregulated in SRF-null epidermis, indicating that SRF may function to repress transcription of a subset of its target genes in epidermis.
In our experiments, the profound reduction of TAMs was associated with complete tumor regression [36].
In addition, subsequent experiments showing profound alterations in the ultrastructure of BMMC granules as a consequence of polyamine depletion with DFMO, also support the presence of polyamines in the granules and suggest that these polycations are important for the correct biogenesis of these organelles.
These experiments indicate profound phenotypic differences, including opposite effects on the number of active zones and glutamate receptor distribution.
The distribution of random effects within the generally resource-limited designs of many transcriptional profiling experiments may have profound effects on the conclusions drawn from these experiments, which would be exacerbated by genotype by environment interaction.
This neat experiment has some profound implications for how banks are run and regulated.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com