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"profound effect on" is a correct and usable phrase in written English
You can use it when you want to express a large, significant, or lasting impact on something or someone. For example, "The tragedy had a profound effect on the entire town."
Exact(60)
It would have profound effect on him.
It had a profound effect on me".
The meeting had a profound effect on him, he said.
This had a profound effect on conservative thinking.
Exclusion can have a profound effect on boys' educational prospects.
Visiting the foundry had a profound effect on Ray.
The crisis has had a profound effect on Zanati.
"The layoff has had a profound effect on me.
This experience had a profound effect on her.
"But it can have quite a profound effect on them.
The novel had a profound effect on me.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com