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The phrase "profound drawback" is correct and can be used in written English
You can use it when referring to an issue or obstacle that is very serious or severe. For example, "The profound drawback to this strategy is that it will take years before we can see any real results."
Exact(2)
Mr. Snyder, the model for Japhy Ryder, the semi-mystical poet in Jack Kerouac's "Dharma Bums," noted that there was a more profound drawback than even politics.
It had one profound drawback, however: a cable snaking from the remote to the set, over which users were inclined to trip.
Similar(56)
Imagine my surprise... ) was his claim that "one of Amis's weaknesses is that he isn't content to be a good writer, he wants to be profound; the drawback to profundity is that it's like being funny: either you are or you aren't, straining doesn't help".
There are profound perks and drawbacks to both, too numerous on both sides to list in earnest.
Therefore, profound approach is required to overcome these drawbacks.
Countering the drawbacks of mail-in voting is the convenience of the thing, which is profound.
The main drawback of NASBA is that special care is needed in sample preparation and detection, due to the profound susceptibility of RNA to degradation.
Profound Lore.
Profound things.
One drawback?
Where is the drawback?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com