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Michael Grandage keeps the character moving around with profound direction, hoping to maintain the fleeting interest of the motel clerk, played by Frank Wood.
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This knowledge can give a more profound direction in approaches aiming at increasing exacerbation related self-management, such as individualized action plans [ 14].
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By the time he was returning to his hometown to see the retired family doctor, he had shown his paintings in New York galleries but was about to take a profound new direction with his art, one that would take him out of the studio, and out of the gallery and the museum itself.
A key turning point in addictions recovery is hitting rock bottom, where the painful awareness of crisis provokes a profound shift in direction.
Introduced as a 1995 model, this was an all-new, radically styled sedan intended to signal a profound change in direction for Olds, a General Motors division that had lost its way.
In either party the ensuing leadership election would be a profound debate about direction, purpose and role, as well as character.
And this in turn had a profound effect on the direction of politics.
To undo the damage will require a profound change of political direction.
Brown's years at SAIC had a profound impact on the direction of his art career.
The outcome of the political fight for the school board seats will have a profound impact on the direction of the nation's second-largest school district.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com