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"profound differences" is a correct and commonly used phrase in written English.
It typically refers to significant or deep contrasts between two or more things. Example: "There were profound differences between the two political candidates' views on healthcare reform."
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The Chinese side behaved differently, Mr. Ford wrote, revealing profound differences in worldview.
We have profound differences.
Profound differences bedevil those efforts.
We have real, profound differences.
Those similarities, though, mask profound differences.
"There are profound differences between the rides," she noted.
It is important to acknowledge profound differences between cases.
There are profound differences between these two likely 2012 nominees.
Beyond these similarities, however, lie some profound differences.
Here there are profound differences between progressives like Dr. Levin and traditionalists like Dr. Hirsch.
It goes without saying that there are profound differences between computers and sculptures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com