Sentence examples for profound defect from inspiring English sources

Tox −/− mice have a profound defect in LTi generation, as indicated by the lack of peripheral lymph nodes and a significantly reduced Peyer's patch frequency and size (Aliahmad et al., 2010).

Both findings indicated a profound defect in actin filament disassembly.

Thus, the triple mutant appears to have a profound defect in its ability to transform primary cells as measured in these assays.

These alterations led to a profound defect in the ability of TIL to produce IFN-γ in response to TCR stimulation.

In contrast, when stimulated with the TLR4 ligand LPS, MoDC from patients show a profound defect in inducing IFNγ secretion by allogeneic T cells.

Using a triple mutant of BCR-ABL (Y177F, ΔSH2, and ΔPro), we show that this mutant still confers growth factor independence to 32D cells (Figure 1), but exhibits a profound defect in the transformation of primary hematopoietic cells.

Though Gingrich raged about King's question, calling it an instance of "the elite media protecting Barack Obama," it is, in fact, conservative, religious voters who have been the most concerned by what they see as profound defects in Gingrich's character and judgment.

E-mail address GO SIGN UP Share Tweet Though Gingrich raged about King's question, calling it an instance of "the elite media protecting Barack Obama," it is, in fact, conservative, religious voters who have been the most concerned by what they see as profound defects in Gingrich's character and judgment.

Introduction Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) recipients have profound defects in every immunity compartments that can lead to severe opportunistic infections (OI).

Chemical or genetic removal of these components induces multiple and profound defects in Photosystem II function and oxygen-evolving complex stability.

Mice homozygous for a mutation (Brdt∆BD1/∆BD1) lacking the first bromodomain of Brdt, a testis-specific member of the BET family of double-bromodomain containing proteins, are sterile and exhibit profound defects in chromatin remodeling during spermiogenesis.