"A profound decrease in slow-wave sleep had an immediate and significant adverse effect on insulin sensitivity and glucose tolerance".
Moreover, pharmacological inhibition of fatty acid synthase (FAS) results in profound decrease in food intake and body weight in rodents.
The resulting thiophilic sulfonamide covalently binds the H+/K+-ATPase, inactivating the proton pump and producing a profound decrease in acid secretion.
A profound decrease in the number of light-responsive ganglion cells was observed during degeneration, culminating in retinas without detectable light responses by P550.
The most profound decrease from the required ratio occurred when companies provided a supplemental ratio that excluded part-time and seasonal employees.
Reducing Mnb levels led to an undergrowth phenotype, with the NMJs showing a profound decrease in the number of synaptic boutons, but an increase in the size of these terminals (Fig. 2).
In our case, steroids were prescribed in view of inflammation involving the disc and macula leading to profound decrease in vision.
The proHGF treatment produced a more profound decrease in pluripotent genes and increase of differentiation genes than did the other experimental treatments (Figs. 2C, 2D, and S4).
By contrast, acute hypotensive anemia (saline hemodilution) resulted in a profound decrease in both brain and muscle tissue PtO2 and evidence of inadequate global perfusion (lactic acidosis).
By contrast, there was a more profound decrease in PvO2 and saturation in the saline hemodiluted group (Tables 1 and 2, Fig. 1, p < 0.05).
The GRK activity and expression of GRK2/GRK6 on POD1 returned to basal levels in many but not all patients.The CPB causes a profound decrease in mononuclear cell GRKs, and the recovery of these kinases on POD1 is quite variable.
