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'profound damage' is correct and usable in written English.
You could use it to describe something that has been significantly or severely damaged. For example, "The earthquake caused profound damage to the city's infrastructure."
Exact(43)
"The most profound damage Kinsey did was to kids," he says.
Plants treated with various phenols suffered profound damage to their chromosomes, changes in genes, and a striking number of mutations.
In April 2011, when the profound damage caused by the police bullet finally killed her, she died without knowing it.
Spending bills winding their way through the House threaten to do profound damage to the president's priorities.
Mohammad Khatami, the former president, called the trial an "unconstitutional" act that would do profound damage to public trust in Iran's system of government.
However justified it believes this war to be, it is a war that has done the cause of peace profound damage.
Similar(15)
If prolonged it leads to profound damages in the myocardium.
We aimed to determine, in a heterogenous critically ill population, whether baseline profound alveolar damage or conductive airway damage has clinical respiratory impact one month after intensive care admittance.
Alcohol is a teratogen, a neurotoxin that can cause subtle developmental disabilities to profound brain damage.
Environmental experts warn construction could cause profound ecological damage by damming rivers, splitting ecosystems and moving untold tons of earth.
Profound brain damage means that in addition to Sophie's severe physical disabilities she has no means of communication.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com