Principal Components Analysis (PCA) was employed to detect outliers because outliers can have a profound influence on correlation coefficients.
This combination of higher volatility and reduced correlation has profound implications for how many stocks an investor needs in a portfolio in order to achieve adequate diversification.
This explains the profound difference in the correlation between sudden death and HR responses during exercise and mental stress.
The initiating phase of SLE may be multifactorial and individually variable, while the presence of excessive apoptotic debris may have profound pathogenic relevance and correlation with disease activity.
Second, subset-based deconvolution allows a novel correlation of the profound changes in blood cell composition created by antibody induction with the molecular pathways activated in critical immune cell subsets.
We have also observed profound changes in the spatial correlation of chromatin density at length scales smaller than 250 nm, which remarkably coincides with the diffraction limit of optical microscopes.
Rasburicase is now a standard of care for patients at high risk of TLS despite continuing debate on the correlation between its profound and rapid lowering of plasma uric acid levels with hard patient outcomes, eg, need for renal replacement therapy and mortality.
It turns out (see Figure 3) that the transition from uncostrained neurotransmission to presence of neurotransmission has profound consequences on the flux correlations within and between cells.
A negative intersexual correlation for fitness has profound implications for models of sexual selection via 'good genes' benefits.
