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The legal charity Reprieve has profound concerns over the use of the base on Diego Garcia in the rendition of those accused of terrorism.
Hayes' letter also repeats his "profound concerns" over a small development of seven wind turbines proposed for West Pinchbeck, in his constituency.
US Secretary of State Hillary Clinton said the US still had "profound concerns" over North Korea, but welcomed the move as a "first step".
"It confirms what we have been telling the UK government all along about our profound concerns over the impact the cuts to council tax benefit will have on some of the most vulnerable members of our society".
However, many Indians still have profound concerns over Mr Modi because of claims he did little to stop communal riots in Gujarat in 2002 in which at least 1,000 people died, most of them Muslims.
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Her foreign secretary, Boris Johnson, summoned the Iranian and Russian ambassadors to express his "profound concern" over the crisis.
And as Mr. Baroni absorbed the news, on a circuitous route home through Abidjan and Paris, he felt both human sadness for Mr. McGreevey, and a profound concern over the State of New Jersey's government.
In a letter to the journal Nature, 13 senior scientists, including Smith and Wilmut, express "profound concern" over the recommended ban, which "represents a blow to years of effort to derive medical applications from embryonic stem cells".
And this raises profound concerns about its legitimacy".
That did not stop him voicing "profound concerns" and lecturing Mr Mittal about his takeover etiquette.
He looks like a very mature writer, with profound concerns, at the height of his powers".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com