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The phrase "profound changes" is a valid and usable phrase in written English.
You could use this phrase in a sentence to describe a situation in which there has been a significant and deep transformation. For example, "The introduction of computer technology has caused profound changes in the world of business."
Exact(56)
Others want to make more profound changes.
There will not be profound changes".
There have also been profound changes in political circumstances.
Some of the most profound changes have been less visible.
Since then, the world has undergone profound changes.
But profound changes take generations; they must involve everybody.
He said the appointment was likely to bring profound changes.
Similar(4)
And yet they have the potential to make profound changes for the better in women's lives.
However, IFN-γ−/− mice obviously expressed more profound changes as would be expected.
Osmond tried LSD himself and concluded that the drug could produce profound changes in consciousness.
If she is right, her research could lead to profound changes in how we treat addiction.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com