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The Times' evolution is emblematic of a slow but profound change, over decades, in élite opinion.
Robert Haigh at Brand Finance, which monitors the health of leading consumer brands, said: "The toy industry has experienced profound change over the last three decades, with digital media and video games being the most transformative force.
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Regarding suburbanisation, land policies in many countries have undergone profound changes over the past 20 years.
Instead, it reflects profound changes over the past century or so in thinking about the respective responsibilities of individuals and institutions and about the role of the state as an increasingly active participant in many areas of business.
If the new rule is enacted, it will be a major success for animal welfare groups, a grave disappointment for some scientists and another sign of the profound changes over the last half-century in the way animals are used and imagined in science and popular culture.
Among the seed plants, whose spores are less mobile, explanations for the current distribution of plants become more complicated and include such profound changes over evolutionary time as the breakup of Pangea some 300 million years ago, the opening of the Atlantic Ocean, and the isolation of North and South America, Australia, and Madagascar from larger continental landmasses.
93.7 4.7 1.6 Have living forms always been as they are now 96.5 3.1 0.4 Are there species living today which did not exist in the past 93.7 4.7 1.6 Can environment conditions undergo profound changes over long periods of time?
But the woman of the journal years underwent profound changes over the next decade of her life.
The landscape of hospital-based care in the US has undergone profound changes over the last 25 years.
Moreover, longitudinal data can also be provided in the graphs, allowing the paediatrician to easily compare multiple HRQOL measurements for one child and detect profound changes over time [ 15].
The CRSN has undergone profound changes over the past decades with staff, infrastructure, and equipment capacity strengthening that allow moving from a local centre to a national centre attractive to international funders.
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CEO of Professional Science Editing for Scientists @ prosciediting.com