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"profound challenges" is correct and usable in written English.
You can use it to describe any difficult or complex situation. For example: "The team faced many profound challenges as they worked on this complex project."
Exact(57)
But profound challenges remain.
Weeks shy of his 16th birthday, Charlie is a loving young man with profound challenges.
Meeting America's profound challenges and reforming Congress will not be easy.
As a landlocked country, Malawi faces profound challenges of high transport costs.
Pakistan faces profound challenges, including militant violence and a crippled economy.
Post-Mubarak Egypt is facing profound challenges with its unfinished revolution and looming economic crisis.
"We are dealing with profound challenges, but from a position of strength".
When a mental illness interferes with judgment and safety, clinicians and families face profound challenges.
If you can download a gun, it presents all kinds of profound challenges to nation-states".
Similar(2)
WHY, according to this article, does it represent "a profound challenge on several fronts"?
Wilson thought that Trump posed a profound challenge for the future of the Republican party.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com