Sentence examples for profound cell from inspiring English sources

In addition, the Trx double knockout displays a profound cell cycle defect, resulting in a prolonged S and a shortened G1 phase [30].

CSMN show early, selective, progressive, and profound cell loss in the absence of UCHL1.

Thus only the ovary exhibits profound cell loss at birth among the organ systems.

All these data suggested that shikonin had very prompt but profound cell killing effect on osteosarcoma cells.

5-FU-treated mice show profound cell proliferation impairment, as demonstrated by ablated mitotic index in the duodenal crypts.

However, at 3 mM cell death became significant and 4 and 5 mM ATP induced even more profound cell death.

Besides late diagnosis, a profound cell-intrinsic and -extrinsic resistance against chemotherapeutic drug and/or death receptor ligand-induced apoptosis contributes to this bad outcome.

The HIV infection is uinque in causing depletion of CD4+ T-cells and induces profound cell-mediated immunodeficiency which permits dysregulated proliferation of B lymphocytes.

NF- κB signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, but little is known about the role of the c-Rel subunit in solid cancer and PDAC apoptosis control.

Our data show that co-targeting EGFR and IGF-1R plus irradiation significantly reduced S phase and arrest cells at G0/G1 phase in MDA-MB-468 cells, profound tumor cell kill was observed, therefore, the cells were sensitized to irradiation.

The majority of patients (11 out of 17) had profound B cell depletion (CD19+ B cell count < 5/μl).