Sentence examples for profound breakdown from inspiring English sources

"It responds to the need to offer new forms of citizen participation at a time of a profound breakdown in the confidence in political institutions," he said.

Although the report described a profound breakdown in the American intelligence system, both White House and Congressional officials say the political calendar will prevent any serious action until after the November elections.

The program began just as soldiers were returning from World War II, a time of "profound breakdown of community," said Laurie F. Maffly-Kipp, a distinguished professor in the humanities at the John C. Danforth Center on Religion and Politics at Washington University in St . Louis

The decision represented the collapse, for now, of a case that was seen as symbolizing both the profound breakdown of law and order after the hurricane and a deep rot within the city's police department that dated back well before the storm.

Magnesium's cytoprotective effect to reduce the profound breakdown of the BBB was first demonstrated in a rat model of severe insulin-induced hypoglycemia [ 4].

The early years were heavily policed and television in the morning was indicative of profound systemic breakdown.

Endocrine disturbances during critical illness lead to a feeding-resistant wasting syndrome, characterised by profound protein breakdown, promoting delayed recovery and poor outcome.

In the moderate and severe stages of AD, the loss of verbal fluency is profound, with breakdown of comprehension and literal and semantic paraphrases prominent (Table 1); in very severe AD, speech is often restricted to echolalia and verbal stereotypy.

In striking contrast, CSMN of UCHL1−/− mice displayed massive disintegration with profound vacuolization and breakdown of cell membrane especially along the apical dendrites (Fig. 4 E, J– O; UCHL1−/−, 42 ± 4%, n = 167 apical dendrites, n = 3; P < 0.01; and WT, 7%, n = 281 apical dendrites, n = 3).

In NMO, astrocytic AQP4 is the primary target of an immune response that results in profound damage to astrocytes, breakdown of the BBB, secondary loss of myelin, and apoptosis of oligodendrocytes [ 12, 17, 20].

Acidosis and hypothermia compound trauma-induced coagulopathy and have profound effects on fibrinogen breakdown and synthesis [ 10], which is supported by the findings of the current study that demonstrated critical and low levels of fibrinogen in 81% and 63% of shocked patients, respectively [ 1].