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Two patients had cerebral ischemia secondary to hypotension because of profound bleeding, with intracranial hemorrhage in 2 additional patients.
The result is an increase in the INR of warfarin as well as prolongs prothrombin time hence increasing the risks of profound bleeding [32].
Three patients developed uncontrollable profound bleeding manifestations and one patient developed grade 4 hepatic encephalopathy prior to death.
Due to the profound bleeding, no clear cause could be identified and, unfortunately, the family of the patient refused a post mortem examination.
Following criteria for euthanasia were applied: severe weight loss over a period of several days, body fat levels below inability to eat or drink, extreme lethargy (i.e. reluctance to move upon gentle prodding), profound bleeding from open sores or tumors.
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In their 2-center comparative study of moderate versus deep HCA in 776 patients, Milewski et al. [ 6] found no significant difference in the incidence of reoperation for bleeding (profound versus deep HCA: 3.8 versus 4.3%; p = 0.783).
This may also explain that, although being small, the sample size had enough power to show some differences in coagulation and fibrinolysis markers, particularly the profound differences in platelet counts observed between bleeding and non-bleeding patients.
As expected, rats given TNBS developed severe colitis, characterized by a profound and sustained weight loss, bleeding, and diarrhoea.
Touring his village, he comments on the toxicity of the bracken (which he associates with bleeding hands) and of the profound effect that sheepherding has had on the landscape, which has been left nearly barren by the grazing animals.
However, such a restrictive transfusion policy was associated with an increased risk of moderate-to-severe bleeding in patients with prolonged and profound thrombocytopenia as seen in acute leukemia.
Other complications of ECV are either uncommon (e.g. transient fetal bradycardia [12%] or dizziness and palpitations from tocolysis [4%]) or rare (<1%) (e.g. profound fetal bradycardia, preterm labour, premature rupture of membranes and bleeding)[ 26].
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