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The phrase "profound antipathy" is correct and usable in written English
It can be used to describe a deep-seated dislike or aversion towards someone or something. Example: "Her profound antipathy towards the new policy was evident in her passionate speech against it."
Exact(6)
The horrors of the Nazi period have imbued today's Germans with a profound antipathy to war and foreign entanglements.At the beginning of this decade, however, the giant stirred.
Within the Democratic base, the exasperation with Clinton for his character defects has paled when measured against the profound antipathy for Bush.
Diplomats who have spent years in the country working with Afghans give the Americans credit for trying, but they warn that it is easy to underestimate the complexity of Afghan tribal relationships and the profound antipathy for the government.
Over the years you've restricted your profound antipathy towards "the bloody royals" to throwing a slipper at the telly the odd time "Prince" Andrew's over-privileged, under-shot mug pops up on it.
Mix fear of the Cold War, revulsion against old men in power and the stultified society that sustained them, profound antipathy to the Vietnamese conflict, and you had a cocktail of grievances ready mixed.
To the degree that she will consent to define herself — and escaping definition is one of her central preoccupations — it is not only as a writer who doesn't traffic in big ideas but as one with a profound antipathy toward intellectualizing.
Similar(52)
And this leads to a social antipathy that can be quite profound.
But, beyond Trump, there is Trumpism: a profound hostility toward political professionalism; a strong antipathy toward technocratic élites; a disenchantment with liberal values.
The antipathy is personal.
Profound Lore.
Profound things.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com