Sentence examples for profound and substantial from inspiring English sources

There is, it transpires, a profound and substantial relationship between Philida and Frans; and its passing is, arguably, more painful for him than her.

Pondering the Virgin Mary's ascension as literal fact, the work pits trombone plainsong against brazen trumpet arias in a restless, profound and substantial chamber-ensemble tour de force.

There is an assumption in the literature that the UML is the de facto standard, and that use of design models has had a profound and substantial effect on how software is designed by virtue of models giving the ability to do model-checking, code generation, or automated test generation.

Annan can make the vaguest, most innocuous statements sound substantial and profound, and he can deliver his toughest, most challenging arguments without apparent argumentativeness.

There is profound uncertainty about how to define the zero point and substantial prognostic uncertainty about whether or not an infant will fall above or below it.

Taken together, our findings showed that fungal infection had a profound effect on the overall health of bee larvae causing rapid decrease in the rate of larval feeding, and substantial decrease in transcription of storage proteins.

It's creative and substantial commercially".

These pH fronts are immediate and substantial.

Heterozygous Dmdo mutants exhibit a progressive and substantial hearing loss that correlates with stereocilia degeneration and auditory hair cell loss in the cochlea, whereas homozygous Dmdo mutants exhibit earlier degeneration leading to complete hair cell loss and profound deafness.

In point of fact the reforms, although substantial, have been far from profound and have proven insufficient to break the bottlenecks that have impaired the region's development for far too long.

Her story is so profound and touching".