Sentence examples for profound abnormality from inspiring English sources

In our preliminary study among medication-free, detoxified female homicidal offenders with antisocial personality disorder, the same profound abnormality in sleep architecture was found.

A profound abnormality in the autophagic pathway also occurs in skeletal muscle in humans with the disease [13], [28].

Despite the lack of effect on platelet number, JAK2 V617F expression caused profound abnormalities of megakaryocyte maturation and platelet function, manifested by small megakaryocytes, abnormal mitoses during proplatelet formation, and a markedly prolonged tail bleeding time.

Imperial College London A study has discovered profound abnormalities in brain activity in a group of retired American football players.

Cocaine-use disorders are associated with profound abnormalities in sleep and sleep architecture.

The right-sided participants had profound disturbances of social and interpersonal behavior and of the ability to maintain gainful employment; they had defective performance and impaired anticipatory skin conductance responses during the Gambling Task; most had profound abnormalities of emotional processing and personality, and met criteria for "acquired sociopathy".

For example, the potassium channel KCNQ has profound effects on the age-related decline in rhythmicity without affecting contractile strength [56], while mutations in the fly dystrophin gene lead to profound abnormalities in contractile force [73].

K6W-Ub has a structure that is indistinguishable from the Wt molecule and readily supports ubiquitination, but incorporation of Ub with mutations at K6 results in perturbed UPP function and profound abnormalities in proteostasis, differentiation, and developmental as well as in age-related protein precipitation disease phenotypes.

More profound abnormalities are expected as chronic migraine is regarded as a clinical worsening.

The absence of the normal protein provokes even more profound abnormalities during hematopoiesis, as witnessed by the limited ability of these cells to expand in culture.

Patients experiencing arsenic toxicity manifest profound abnormalities in repolarization of the heart, resulting in life-threatening malignant ventricular arrhythmias (Ohnishi et al. 2002; St. Petery et al. 1970).