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This PROFIT trial is designed as an RCT.
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The U-PROFIT trial was designed to evaluate the effectiveness of these interventions.
In this paper, we present the research design and methodology of the U-PROFIT trial.
We met several challenges during the design and implementation of the U-PROFIT trial.
These are also the eligibility criteria of the U-PROFIT trial as described earlier (multimorbidity, polypharmacy and a care gap).
The aim of this paper is to describe the U-PROFIT trial design and to discuss methodological issues and challenges.
MN, MS and NW designed the study and wrote the grant application for the U-PROFIT trial.
The aim of this paper is to describe the design of the U-PROFIT trial, the content of the two interventions and its methodological challenges.
Two interventions are being tested in the U-PROFIT trial: 1. Screening and Monitoring of frailty (U-PRIM) and 2. Nurse-led multidisciplinary intervention program (U-CARE).
The primary outcome of the U-PROFIT trial is the level of Activities of Daily Living (ADL) as measured with the Katz ADL index score [ 35].
These patients are approached by their GP with a patient information letter and informed consent form for participation in the U-PROFIT trial.
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