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He wanted to know why, if the F.B.I.'s approach to criminal profiling was based on such simplistic psychology, it continues to have such a sterling reputation.
Ribosome profiling was based on the method of Ingolia (Ingolia et al., 2009), but with modifications (see below).
The coexpression profiling was based on the combination of six different cell lines representing ES or EB.
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As the predictions using concept profiling are based on conceptual relatedness rather than an explicit co-occurrence in MEDLINE, this case study is indicative of the power of concept profiles to discover new, implicitly related pairs of interacting proteins.
The Illumina genome analyzer protocols for miRNA expression profiling are based on the Modban [ 6] method.
High-throughput sequencing expression profiling is based on 31 independent sequencing samples, from which 21 were generated by our group.
The profiling is based on the extensive analysis by Carbonara et al.[ 13] and on our earlier work[ 18] with artemisinin-related compounds in the extracts.
However, it is important to note that the level of translational regulation in our ribosome profiling is based on the sum of the reads over all mRNA isoforms.
Ribosome profiling is based on deep sequencing, and thus provides an unmatched level of resolution of the translated peptides when compared with current proteomics techniques.
Conventional approaches to isoform profiling are based on synthesis of multiple sets of "gene-specific" oligonucleotides priming multiple reverse transcriptase-polymerase chain reactions (RT-PCR).
Ribosome profiling is based on deep sequencing of ribosome-protected mRNA fragments, and allows the analysis of translation at nucleotide resolution.
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