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Peripheral blood is representative of many systemic processes and is an ideal sample for expression profiling of diseases that have no known or accessible lesion.
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Large-scale microarray profiling of disease and norm as well as smaller scale datasets were downloaded from Global Expression Omnibus (GEO) platform at NCBI [34].
Methodologies for large-scale molecular profiling of disease tissues have been well established [ 1- 3] and have been shown to be of utility both diagnostically [ 4] and prognostically [ 5].
Genomic profiling of disease models is of interest for characterizing the pathological response at transcriptome level and identifying putative drug targets.
Such a model enables in vitro generation of human tissue types, which allows patient-specific assays for functional interrogation of genetic variants or expression profiling of disease relevant genes.
There still remains the need to build a linked library network as well as new taxonomy profiles of diseases for the better implementation of precision medicine, although enormous data have been generated and shown contribution to precision diagnosis, pharmaceutical development.
By matching the molecular profiles of diseases and drug actions, NuMedii can reduce the amount of time for drug testing from 3-6 years down to 3-6 months, and its accuracy has been crazy good, with 6 6 probability of success in early tests.
The phenotype similarity profile of diseases has been successfully used for prioritizing candidate genes in recent studies [ 14- 20].
The.cel files of drugs from Connectivity Map were processed used MAS 5.0 suit, and the gene expression profiles of diseases were obtained directly from GEO with soft format.
There are multiple examples of biological interventions that have helped modify the host and change the epidemiological profile of diseases in history.
This is the working definition that we adopt here and is of particular relevance when considering the profiles of diseases recorded in the free-text literature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com